Seattle begins its playoff quest as Super Bowl favorites and welcomes a divisional foe in San Francisco, which just survived a 23-19 trip to Philadelphia.
The Seahawks already forced the Niners into a 13-3 dud in Week 18, a result that secured home-field advantage and framed why Seattle is a 7.5-point favorite at Lumen.
San Francisco’s path here has leaned on road toughness all season, but this is its third crack at Seattle, splitting the regular-season matchups.
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What our Post expert thinks about 49ers vs. Seahawks
Seattle’s edge starts with a defense that has held the 49ers to 20 total points in two meetings, now facing a San Francisco offense without George Kittle and already missing multiple defensive anchors of its own.
Sam Darnold’s late-season dip is real, yet Seattle has still leaned on Jaxon Smith-Njigba, who torched this matchup for 208 yards across two games.
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Why Trust New York Post Betting
Sean Treppedi handicaps the NFL, NHL, MLB and college football for the New York Post. He primarily focuses on picks that reflect market value while tracking trends to mitigate risk.
