The sliding Mets had their series opener Tuesday against the Brewers postponed by forecasted rain.
The game will be made up as part of a day-night doubleheader on Wednesday at 1:10 p.m. and 7:10 p.m. at Citi Field.
Clay Holmes and Blade Tidwell will start the two games for the Mets, who have lost 13 of their past 16 games following a weekend sweep by the Pirates.
Freddy Peralta and Jacob Misiorowski will start for Milwaukee.